Antidiabetic Effect of Casein Glycomacropeptide Hydrolysates on High-Fat Diet and STZ-Induced Diabetic Mice via Regulating Insulin Signaling in Skeletal Muscle and Modulating Gut Microbiota
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چکیده
منابع مشابه
Antidiabetic and antineuropathic effect of Onosma dichroanthum extract on acute stress in STZ diabetic mice
Background and objectives: Diabetes is a metabolic disease with hyperglycemia, decrease in insulin secretion or de-sensitization of peripheral cells to insulin.Onosmadichroanthum is a species of Boraginaceae and is used in traditional medicine for its anti-oxidant, anti-inflammatory and antibiotic properties, however data on its anti-diabetic effects ...
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Objective(s): Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex proteins are involved in membrane trafficking. The expression of isoforms of SNAP-23, syntaxin-4, and VAMP-2 is significantly done in skeletal muscles; they control GLUT4 trafficking. It is believed that type 2 diabetes could be caused by the modifications in the express...
متن کاملAltered microRNA expression in skeletal muscle results from high-fat diet-induced insulin resistance in mice.
Skeletal muscle insulin resistance induced by a high-fat diet has been implicated in the development of type 2 diabetes. However, the precise molecular mechanisms involved are only partially understood. Recently, studies have shown that microRNAs play an important role in insulin resistance in various tissues. In this study, microRNA expression profiles of skeletal muscle of mice fed a high-fat...
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Background: Type 2 diabetes (T2D) in the elderly is an epidemic that has major impact on global health. Thus this experimental study aimed to compare the response of microRNA-133a (miR-133a) in different tissues and of Runt-related transcription factor 2 (Runx2) in bone marrow tissue following resistance and endurance training in old rats with high-fat diet and streptozotocin (HFD/STZ)-induced ...
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ژورنال
عنوان ژورنال: Nutrients
سال: 2020
ISSN: 2072-6643
DOI: 10.3390/nu12010220